Basis of rhythmic structure is circadian clock , which is located at suprachiasmatic nucleus ( scn ) and pineal gland in mammal . the molecular basis of which is composed of a series of genes and their corresponding protein products 生物節(jié)律的生理基礎是生物鐘,哺乳動物的主鐘定位于丘腦視交叉上核( suprachiasmaticnucleus , scn )和松果體;生物節(jié)律的分子基礎是一系列與生物鐘相關的基因及其蛋白產(chǎn)物。
In the present study , we determine the clock and melatonin receptor subtypes ( mt 1 , mt2 ) genes in suprachiasmatic nucleus ( scn ) and lymphocytes at different time points of specific light regimes . the aim of this study is to investigate the effects of light on circadian expression of these clock related genes , and to explore possible roles and mechanisms of these genes in regulation of the diurnal rhythm 本課題采用不同的光照制,研究scn及外周淋巴細胞中的鐘基因clock 、褪黑素受體基因( mt1和mt2 )的晝夜表達規(guī)律,以期了解光照對中樞和外周這三個基因晝夜節(jié)律表達的影響,并試圖發(fā)現(xiàn)它們在生物鐘晝夜節(jié)律的維持中可能的作用規(guī)律。